Brown University Wins $6.25 Million MURI grant from Army Research Office

Brown and Cal State Northridge are teaming up on a $6.25 million Multi-University Research Initiative (MURI) grant from the Army Research Office (ARO) to study “Stress Controlled Catalysis via Engineering Nanostructures”. The five-year project will be led by principal investigator Bill Curtin, with collaborators Pradeep Guduru and Sharvan Kumar in the School of Engineering, Shouheng Sun in Chemistry and Engineering, and Gang Lu in Physics at Cal State Northridge. Four graduate students and six postdocs will join the faculty in executing the research.

Professor Bill Curtin '81

“This new award contributes to the growing portfolio of engineering research at Brown in the energy and nanosciences fields,” said Dean Larry Larson. “These new fields are changing the way we live in thousands of different ways. Congratulations to all the faculty, post-docs, staff and students involved in these successful efforts.”

The goal of the research is to demonstrate that macroscopic applied mechanical loading can be used to actively control and tune catalytic reactions through the use of innovative nanoscale material systems.


The challenge lies in obtaining stresses in the catalytic metal materials that are large enough to significantly influence the rates of selected chemical reactions in an overall catalytic process.

Associate Professor Pradeep Guduru

Professor Sharvan Kumar

Brown researchers will accomplish this by creating ultra-strong nanostructured materials in novel geometries where the mechanical load can be controlled and varied, also serving to isolate strain as the only experimental variable.

If the principle is demonstrated, then it may be possible to increase catalytic efficiencies by using time-varying stresses to actively control the reactions during operation, opening up the field of catalysis to an entirely new space of materials design.

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Nanomaterials Studies Advance Cancer Research

Graduate student Lijuan Zhang and associate professor Thomas Webster have conducted research with nanomaterials that may lead to a potential breakthrough in cancer research. Their recent research, "Decreased lung carcinoma cell functions on select polymer nanometer surface features" was published in Journal of Biomedical Materials Research A.  

Behind the purple doors of a sixth-floor Barus and Holley Lab, Thomas Webster, associate professor of engineering, works small but thinks big. His work with nanomaterials, tiny devices implanted into the human body, has led to a potential breakthrough in cancer research.

Webster, director of the University's NanomedicineLaboratory, has been studying and developing nanotech implants for the past 11 years. His team had created rough implants covered in tiny "nano-features"— microscopic bumps ­— to "mimic the natural roughness of healthy skin," he said. "Current orthopedic implants are flat and smooth, but healthy skin and bone have bumps."

Two years ago, graduate student Lijuan Zhang approached Webster with a radical idea — exploring how nano-features would interact with cancer cells.

"Being the adventurous person I am, I said, ‘Let's try it,'" Webster said. It was completely new territory for Webster, but he said he was excited to see what would happen.

Within a year of research, a blink of an eye in lab time, Zhang approached Webster with results they both found fascinating. The addition of 23nm nano-features to a petri dish with both cancerous and healthy cells caused a significantly lower density of cancer cells over time.

Webster said he was pleased and intrigued by the results, but he knew the tests needed to be run at least three more times to verify any findings.

Zhang ran another trial and again found a lower density of cancer cells, but she also found something new — the nano-features inhibited the synthesis of a protein that aids in tumor growth.

The tests had initially been conducted with lung cancer cells, but later tests used breast cancer and bone cancer cells. Both reacted in the same manner — the nano-features lowered the density of cancer cells and decreased the synthesis of the tumor growth protein.

The next step is finding real-world applications, Webster said. "In order for any of this research to be useful, we need a company. We need to transition from the lab bench to a real product."

Webster said he hopes to apply their discovery to animal models and eventually human trials. "If all goes well, a product could appear in five years," he said.

By Hannah Kerman/BDH

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Rick Fleeter ’76 PhD ’81 Publishes Third Book

Rick Fleeter ’76 PhD ’81, a Brown University engineering alumnus and an adjunct associate professor in the School of Engineering at Brown, has recently published his third book, Love Is Strong As Death. Written with his late wife Nancy, the book discusses their 15-year battle with cancer.

“This book is our experience, two innocent novices, in dying, death and rebuilding one life where once there had been two,” said Fleeter. “It offers no advice, only a window into this most personal, and at the same time universal, of human experiences.”

Rick and Nancy were both professionals whose work took them all over the world. He founded and managed the aerospace engineering company AeroAstro, while Nancy managed arts organizations including American Ballet Theater and the J.F. Kennedy Center. Rick also wrote books and taught aerospace engineering as an adjunct professor, while Nancy continued to practice and teach ballet.

They lived at various times, sometimes simultaneously, in suburban Washington, D.C., Manhattan, Charlestown, R.I., Rome, Tokyo, and Gold Coast, Australia.

In addition to this book written with Nancy, Rick has written several books and book chapters on the engineering and management of miniature spacecraft and on cycling, triathlon and living nomadically for business and pleasure.

Rick now writes and is a professor in Rome and Rhode Island, teaching at The University of Rome La Sapienza and Brown University.

Rick also blogs at: http://rfleeter.wordpress.com

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Brown University Engineering Ranked Among Top 50 Engineering Universities in the World; Top 3 in Ivy League

Times Higher Education has released its 2011-12 top 50 world university engineering and technology rankings, and Brown was ranked No. 45 in the world. There were a total of 22 U.S. universities on the prestigious list, including three Ivy League universities: Princeton, Cornell and Brown.

For the full list of the engineering and technology rankings, please go to:
http://www.timeshighereducation.co.uk/world-university-rankings/2011-2012/engineering-and-it.html

“We are proud to have been recognized as among the top engineering schools in the world,” said Associate Dean Eric Suuberg. “Considering that we have had the status of a School of Engineering for only a few months, and particularly noting that virtually all of the institutions that ranked ahead of us have much larger programs than do we at Brown, we are very pleased with the result.”

“It is particularly gratifying to see that we are one of the three top-ranked engineering schools among our Ivy League peers, a group that is somewhat distinct from many of the other highly ranked schools,” said Dean Larry Larson. 

For the full list of the overall college rankings, please go to:
http://www.timeshighereducation.co.uk/world-university-rankings/2011-2012/top-400.html

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Brown Engineer Nathanial Cooper ’12 Finishes Third at AIChE Competition

Students in the Brown chapter of the American Institute of Chemical Engineers (AIChE) traveled to Minneapolis, Minnesota, to attend the national AiChE meeting and compete in a student poster competition.

In the environmental category, Nathanial Cooper ’12 won a third place award. His poster was entitled, “Agricultural Waste Based Bio-Char Sorption Potential”. Last year, Cooper finished second in the poster competition.

Four students represented Brown at this year’s competition, including: Henry Mattingly ’12 (supervisor Robert Hurt), William Trinh ’12 (supervisor Indrek Kulaots), Cooper (supervisor Indrek Kulaots), and Ellison Kandler ’13 (supervisors Steve Greenbaum of the City University of New York and Eric Suuberg).

“As I've attended these student conferences over many years, and I do carefully review most of these posters presented, I must say that this year was even beyond what I have seen before,” said Kulaots. “The competition has gotten more and more competitive every year, and the level of science presented by undergraduates is remarkable.”

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Ancient Lamps, Earrings Yield Their Secrets Under Neutron Imaging

“Neutron imaging gives researchers new tools for exploring artifacts and ancient technology”

Brown University School of Engineering Professor Brian Sheldon is the co-principal investigator on an exciting colloborative project that also includes Brown's Joukowsky Institute for Archaeology

For the first time at Oak Ridge National Laboratory (ORNL), neutron images in three dimensions (3-D) have been taken of rare archaeological artifacts. Bronze and brass artifacts excavated at the ancient city of Petra, in present day Jordan, were recently imaged in 3-D using neutrons at the High Flux Isotope Reactor’s CG-1D neutron imaging instrument.

The neutron imaging technique gives eager archeologists and ancient historians significant, and otherwise wholly inaccessible, insight into the manufacturing and lives of cultures that once occupied settlements within the Roman Empire, Middle East, and Colonial-Period New England.  

The samples imaged in 3D in August came from the collections of the Joukowsky Institute for Archaeology and the Ancient World at Brown University. They include an elaborate hanging bronze oil lamp, a large Roman coin, and—most charmingly—a standing dog figure, which might have been either a religious dedication or perhaps a toy. Although their original provenance is unknown, they are all excellent examples of common metal finds from antiquity.

Principal investigator (PI) Krysta Ryzewski, an assistant professor of anthropology at Wayne State University, and her co-PI Brian W. Sheldon, professor of engineering at Brown University, were loaned the artifacts for study from professor Susan E. Alcock, director of Brown’s Joukowsky Institute. 

In earlier work, the team conducted two-dimensional imaging of copper alloy (bronze and brass) artifacts both from Petra and from Greene Farm, a colonial-period plantation in Rhode Island. The samples include artifacts from daily life: a clothing buckle, a knife, and some building hardware.

Top: photo of ancient Greek lamp. Bottom: neutron radiograph of the same lamp.

One circular object from Petra was so corroded that it was unidentifiable. But when it was imaged with neutrons, underneath was a piece of jewelry, probably an earring. Petra is most famous as a trading center in ancient times, connecting the Mediterranean world with places as far away as India and China. It was the capital of an independent kingdom of the Nabataeans, until the emperor Trajan incorporated it into the Roman Empire in the early second century A.D.

The earlier imaging and analysis resolved some questions of object identity and raised many new ones about the techniques and materials that crafts people in the past used to make these objects. “We can also examine certain objects (such as the knife or the bronze lamp) to look for trace residues of the oil once burned in the lamp or what the knife was used to cut,” says Ryzewski.

“I first learned of the developing neutron imaging instruments at Oak Ridge in my conversations with Hassina Bilheux (lead instrument scientist for CG-1D). At the time I was a postdoctoral fellow in archaeology and engineering at Brown. I attended a neutron imaging workshop at SNS in November 2008, and became the only archaeologist to be part of the VENUS instrument development team. Brian Sheldon at Brown also joined then. We have been collaborating on all of the experiments with Hassina at SNS and HFIR,” she says.

The neutron imaging beam line is a huge step forward for these scholars. “Archaeologists and scientists can obtain relatively little information about the manufacture of archaeomaterials, ancient objects, and the materials from which they are constructed from external surfaces alone,” says Ryzewski. “Very few historical accounts describe the construction of such objects and archaeomaterials, ancient bronzes, or ceramic vessels. The only source of information about how these objects were constructed comes from their material properties and composition.”

Archaeological objects are reviewed as unique cultural resources. Earlier analysis often entailed extracting a sample from such an object, which meant damage and sometimes even wholesale destruction of an artifact so it could be mounted effectively for analysis. Analysts’ necessarily conservative treatment of archaeomaterials left many questions unanswered.

Imaging archaeological objects comprehensively and systematically with neutrons only became possible with the development of the CG-1D prototype beam line. Neutron activation analysis and neutron imaging at Oak Ridge means scholars can now conduct detailed, nondestructive analysis of samples. “There currently exist a vast array of archaeological objects and research questions about ancient and historical technological development that can now be posed,” says Ryzewski. “The CG-1D beam line has offered us an invaluable alternative for performing nondestructive, noninvasive analysis.”

CG-1D data can reveal the raw materials used, the manufacturing techniques, the historical development of alloys and composite materials and the geological origins of ores and clay. On the cultural side, researchers can learn about the activities of ancient people’s daily lives that such objects served.

“Archaeologists can now begin to precisely reconstruct past networks and patterns of resource extraction, trade and exchange, environmental impacts of industrial activities on ancient landscapes, and the transmission of craft production traditions over time,” Ryzewski says. “These are some of the sorts of questions that our current research and experiments are designed to address.“

The 3-D neutron imaging and quantitative analysis occurs at an instrument that is a time-of-flight beam line, with a chopper for producing pulses of neutrons to take noninvasive images. Neutrons, rather than x-rays, do the work.

“Part of our early work was to test the parameters of the instrument and how we might need to adjust the instrumentation to suit the artifacts, which tend to vary in composition, size, and density,” Ryzewski says. 

“We anticipated that we would be able to see beneath the surface and find evidence of manufacturing steps (mold seams), impurities or other organic inclusions in the metals, residue from the objects’ use, and microstructural or compositional elements,” she says.

Their data are still being processed, but preliminary results from the bronze lamp suggest that they will be able to see and examine aspects of all of these areas of interest once the 3-D data are compiled. 

“Our work is still in its early stages. We hope to reexamine these objects in further rounds of testing in 2012. We will expand our sample base to other types of metal artifacts, perhaps some excavated from shipwrecks. We hope to examine ceramic artifacts as well, Ryzewski says.

More broadly, the scholars may be in a position to offer information to scientists who specialize in the conservation and stabilization of museum collections. Other findings may provide insights into materials behavior of interest to materials science. “Each round of experiments raises many more questions about the materials in the object and about the instrumentation itself,” Ryzewski says.

This fall the researchers will return to HFIR to image some of the bronze objects for Bragg-edge peaks in the materials. Collaborating with Ryzewski and Sheldon are Bilheux and Lakeisha Walker of SNS and Susan Herringer, a doctoral student in materials science engineering at Brown and the Joukowsky Institute.

The group will publish their results in both archaeological and neutron sciences academic publications. In addition, they will present their initial findings at the annual Society for American Archaeology meetings in Memphis in April 2012.

Courtesy of Oak Ridge National Laboratory/Written by Agatha Bardoel

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Professors Kenny Breuer and Eric Suuberg Named Associate Deans of Engineering

Brown University School of Engineering Dean Larry Larson has announced that Professor Eric Suuberg has agreed to accept an appointment as Associate Dean of Engineering for Research and Graduate Initiatives and Professor Kenny Breuer has agreed to accept an appointment as Associate Dean of Engineering for Academic Programs. Both will serve three-year terms.

“I want to thank them both for their willingness to serve the School of Engineering, and for the commitment of their time and energy in moving the School forward in the coming years. Professors Suuberg and Breuer bring decades of experience and wisdom to the School leadership.” said Larson.

The Associate Dean of Engineering for Research and Graduate Initiatives will be responsible for enhancing and expanding the research and graduate enterprise and profile of the School of Engineering, including development of an enhanced master’s program for the School of Engineering and development of a plan for improved engineering research laboratory and instructional space.

The Associate Dean of Academic Programs will be broadly responsible for the academic mission of the School of Engineering, and will work closely with the Director of Undergraduate Programs, Director of Graduate Programs and the Curriculum Committee on curriculum development, educational outreach, student career development and instructional technology.  

Professor Breuer received his Sc.B. from Brown and his M.Sc. and Ph.D. from M.I.T. He spent nine years on the faculty of M.I.T. in department of Aeronautics and Astronautics, before returning to Brown in 1999. His research interests are in fluid mechanics, covering a wide range of topics, including the physics of flows at micron and nanometer scales, animal flight (bat flight in particular), and the physics and control of turbulent flows. He is author of over one hundred refereed technical publications, has edited and co-authored several books, including “Microscale Diagnostic Techniques”, “A Gallery of Fluid Motion”, and “Multimedia Fluid Mechanics”. Breuer was elected a fellow of the American Physical Society in 2010.

Professor Suuberg has been at Brown since 1981, when he was one of the founding members of Brown's Chemical Engineering program. His research interests have been in the areas of energy and environmental engineering. He has served as Associate Dean of the Faculty (2002-2005), as Chair of the Psychology Department (2004-5) and as a member of the Executive Committee of the Division of Engineering. He is currently Co-Director of the Superfund Basic Research Program, and a co-founder of the Commerce, Organizations and Entrepreneurship concentration as well as a co-founder of the PRIME master’s program. He is a principal editor of the journal Fuel. He was elected fellow of the American Chemical Society (ACS) in 2011.

Professor Suuberg's research interests center on energy and environmental areas, involving study of fuel chemistry (coal, oil shale, biomass), activated carbons (production and properties), materials reuse (automobile tires, coal fly ash), fire safety and, most recently, the characterization and cleanup of lands and sediments contaminated with mixed pollutants with a focus on thermodynamics of mixtures of high molecular weight organic compounds and the related problem of vapor intrusion.

He received his bachelor’s degree in chemical engineering from M.I.T., a master’s degree in management science from M.I.T., and an Sc.D. in chemical engineering from M.I.T.

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